abstract：:Long-acting bronchodilators in combination with inhaled corticosteroids (ICS) are recommended to decrease the risk of recurrent exacerbations in patients with Global initiative for chronic Obstructive Lung Disease (GOLD) stage 3-4 chronic obstructive pulmonary disease (COPD). There is increasing concern about the clin...

journal_title：Respiratory medicine

authors： Magnussen H,Watz H,Kirsten A,Decramer M,Dahl R,Calverley PM,Towse L,Finnigan H,Tetzlaff K,Disse B

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Neuromuscular electrical stimulation (NMES) improves muscle performance and exercise tolerance in chronic obstructive pulmonary disease (COPD) patients. In contrast, no study has assessed the effect of NMES on dynamic hyperinflation (DH) in COPD. This study investigated the effect of short-term, high-frequen...

journal_title：Respiratory medicine

authors： Vieira PJ,Chiappa AM,Cipriano G Jr,Umpierre D,Arena R,Chiappa GR

更新日期：2014-04-01 00:00:00

abstract：UNLABELLED:Amiodarone-induced pulmonary toxicity (APT) is a serious adverse event that can lead to death. The aims of our study are to determine factors associated with mortality and to describe outcome and sequelae of patients with APT. METHODS:Forty-six patients with APT were divided into two groups according to sur...

journal_title：Respiratory medicine

authors： Mankikian J,Favelle O,Guillon A,Guilleminault L,Cormier B,Jonville-Béra AP,Perrotin D,Diot P,Marchand-Adam S

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Anxiety and depression are prevalent in patients with asthma, and associated with more exacerbations and increased health care utilization. Since psychiatric intervention might improve asthma control, we examined whether patients with severe, prednisone-dependent asthma are at higher risk of these disorders ...

journal_title：Respiratory medicine

authors： Amelink M,Hashimoto S,Spinhoven P,Pasma HR,Sterk PJ,Bel EH,ten Brinke A

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:We explored the prevalence, clinical and physiologic correlates of pulmonary hypertension (PH), and screening strategies in patients with severe emphysema evaluated for the National Emphysema Treatment Trial (NETT). METHODS:Patients undergoing Doppler echocardiography (DE) and right heart catheterization we...

journal_title：Respiratory medicine

authors： Minai OA,Fessler H,Stoller JK,Criner GJ,Scharf SM,Meli Y,Nutter B,DeCamp MM,NETT Research Group.

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Breathing-retraining and helium-oxygen (heliox) have been used to improve exercise tolerance in COPD. We hypothesized that, in patients with COPD, exercise duration after exercise-training plus breathing-retraining and oxygen would be longer than after exercise-training plus heliox or after exercise-training...

journal_title：Respiratory medicine

authors： Collins EG,Jelinek C,O'Connell S,Butler J,McBurney C,Gozali C,Reda D,Laghi F

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Combination inhaled corticosteroid/long-acting bronchodilator (ICS/LABA) therapy reduces the exacerbation rate and improves spirometry and quality of life in COPD. We hypothesized that ICS/LABA therapy also improves small airway function measured by FOT. METHODS:14 subjects with COPD were commenced on com...

journal_title：Respiratory medicine

authors： Timmins SC,Diba C,Schoeffel RE,Salome CM,King GG,Thamrin C

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Subjective fatigue has been recognised as an important, multi-component symptom in COPD. Pulmonary Rehabilitation (PR) improves fatigue component of the Chronic Respiratory Questionnaire, a quality of life (QoL) measure. However, it is not clear if all fatigue dimensions are affected equally. This study ai...

journal_title：Respiratory medicine

authors： Lewko A,Bidgood PL,Jewell A,Garrod R

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To compare the prognostic value of FENO with bronchoprovocation testing when the clinical course within the first year after assessment was taken into account; to compare the prognostic values with respect to eosinophilic versus non-eosinophilic inflammatory pattern. METHODS:Cross-sectional diagnostic study...

journal_title：Respiratory medicine

authors： Schneider A,Faderl B,Schwarzbach J,Welker L,Karsch-Völk M,Jörres RA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The 6 min walk test (6MWT) provides prognostic information in various respiratory diseases, but limited data exist in cystic fibrosis (CF) adults. METHODS:Consecutive CF adults who performed 6MWT at Cochin Hospital (Paris, France) over 12 years were analyzed. The cut-off 6 min walking distance (6MWD) value ...

journal_title：Respiratory medicine

authors： Martin C,Chapron J,Hubert D,Kanaan R,Honoré I,Paillasseur JL,Aubourg F,Dinh-Xuan AT,Dusser D,Fajac I,Burgel PR

更新日期：2013-12-01 00:00:00

abstract：AIMS:This study tested inhibitory effects of in vitro Montelukast treatment on nasal airway epithelial cells (AEC) cultured from asthmatic patients treated with Montelukast with and without concomitant allergic rhinitis. We further examined the effect of Montelukast withdrawal in these patients on cytokine release from...

journal_title：Respiratory medicine

authors： Scaife A,Miller D,Spiteri-Cornish D,Turner SW,Devereux GS,Walsh GM

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:We aimed to investigate the results of anti-tumor necrosis factor (TNF) therapy in patients with a previous history of tuberculosis (TB). METHODS:A total of 101 patients with a previous history of TB receiving TNF antagonists between December 2004 and September 2012 at the Asan Medical Center in South Korea...

journal_title：Respiratory medicine

authors： Jo KW,Hong Y,Jung YJ,Yoo B,Lee CK,Kim YG,Yang SK,Byeon JS,Kim KJ,Ye BD,Lee SD,Kim WS,Kim DS,Shim TS

更新日期：2013-11-01 00:00:00

abstract：AIM:To describe how patients with COPD, heart failure, dementia and cancer differ in frequency and timing of referral to palliative care services. METHODS:We performed a population-based study with the Sentinel Network of General Practitioners in Belgium. Of 2405 registered deaths respectively 5%, 4% and 28% were iden...

journal_title：Respiratory medicine

authors： Beernaert K,Cohen J,Deliens L,Devroey D,Vanthomme K,Pardon K,Van den Block L

更新日期：2013-11-01 00:00:00

abstract：:The purpose of this study was to explore respiratory health effects of indoor exposures to aldehydes and volatile organic compounds (VOCs) in elderly living in a population-based representative sample of French dwellings and to compare them to the rest of the occupants of the dwellings. Twenty VOCs were objectively me...

journal_title：Respiratory medicine

authors： Bentayeb M,Billionnet C,Baiz N,Derbez M,Kirchner S,Annesi-Maesano I

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:GINA guideline recommends stepping down treatment of asthma patients where control is achieved. The aim of this analysis was to estimate the costs and health outcomes associated with step down of controlled patients on high dose fluticasone/salmeterol (FP/S 1000/100 μg daily) to either medium dose FP/S (500/...

journal_title：Respiratory medicine

authors： Paggiaro P,Patel S,Nicolini G,Pradelli L,Zaniolo O,Papi A

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Alpha1-antitrypsin (AAT) deficiency, although largely under-diagnosed, is the underlying cause of approximately 1% of COPD cases. Lack of awareness leads to long delays in diagnostic testing. Subsequently, lifestyle and treatment choices with potentially positive effects on prognosis may be postponed. METHO...

journal_title：Respiratory medicine

authors： Greulich T,Ottaviani S,Bals R,Lepper PM,Vogelmeier C,Luisetti M,Ferrarotti I

更新日期：2013-09-01 00:00:00

abstract：:Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...

journal_title：Respiratory medicine

authors： Cazzola M,Calzetta L,Lauro D,Bettoncelli G,Cricelli C,Di Daniele N,Rogliani P

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous respiratory disease with important extra-pulmonary features and comorbidities. The aim of this study was to assess clinical heterogeneity in a well-defined subgroup of individuals with COPD GOLD D, including possible gender differe...

journal_title：Respiratory medicine

authors： Sillen MJ,Franssen FM,Delbressine JM,Uszko-Lencer NH,Vanfleteren LE,Rutten EP,Wouters EF,Spruit MA

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Limited data are available as to the relationship between computed tomography (CT) derived data on emphysema and airway wall thickness, and quality of life in subjects with chronic obstructive pulmonary disease (COPD). Such data may work to clarify the clinical correlate of the CT findings. METHODS:We inclu...

journal_title：Respiratory medicine

authors： Gietema HA,Edwards LD,Coxson HO,Bakke PS,ECLIPSE Investigators.

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Intermittent ICS treatment with SABA in response to symptoms, is an emerging strategy for control of mild-to-moderate asthma, and recurrent wheezing. This systematic revue compares the efficacy of daily vs. intermittent ICS among preschoolers, children and adults with persistent wheezing and mild to moderate...

journal_title：Respiratory medicine

authors： Rodrigo GJ,Castro-Rodríguez JA

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The diagnosis of pulmonary aspergillosis is difficult because the sensitivity of the conventional methods for the detection of Aspergillus such as culture and cytology, is poor. To improve the sensitivity for Aspergillus detection, the detection of galactomannan antigen has been investigated. The serum galac...

journal_title：Respiratory medicine

authors： Kono Y,Tsushima K,Yamaguchi K,Kurita N,Soeda S,Fujiwara A,Sugiyama S,Togashi Y,Kasagi S,To M,To Y,Setoguchi Y

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Physical activity and health status deteriorate early in the course of chronic obstructive pulmonary disease (COPD). This can only partially be explained by the degree of airflow limitation. Changes in (resting and dynamic) lung volumes are known to be associated with functional impairments and thus might in...

journal_title：Respiratory medicine

authors： Lahaije AJ,van Helvoort HA,Dekhuijzen PN,Vercoulen JH,Heijdra YF

更新日期：2013-06-01 00:00:00

abstract：:Anxiety and depression can increase the intensity of dyspnea out of proportion to the impairment in cardiorespiratory function and may contribute to the degree of disability associated with dyspnea. The effect of anxiety/depression on the sensory and affective components of reported dyspnea in patients with respirator...

journal_title：Respiratory medicine

authors： Scano G,Gigliotti F,Stendardi L,Gagliardi E

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Cleaning workers have an increased risk of asthma but the underlying mechanisms are largely unknown. We studied functional and biological characteristics in asthmatic cleaners and compared these to healthy cleaners. METHODS:Forty-two cleaners with a history of asthma and/or recent respiratory symptoms and 5...

journal_title：Respiratory medicine

authors： Vizcaya D,Mirabelli MC,Orriols R,Antó JM,Barreiro E,Burgos F,Arjona L,Gomez F,Zock JP

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Patients with severe or very severe chronic obstructive pulmonary disease (COPD) frequently suffer repeated exacerbations generating high health care utilization costs. Combined corticosteroid and bronchodilator treatment using a single inhaler might - via improved compliance - reduce exacerbation rates. OB...

journal_title：Respiratory medicine

authors： Hagedorn C,Kässner F,Banik N,Ntampakas P,Fielder K

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Discrepancies have been observed between clinical, physiological, and inflammatory asthma control criteria, mostly in asthmatic subjects using regular inhaled corticosteroids (ICS) treatment. This study compared the prevalence of discrepancies between these 3 control parameters in mild asthmatic subjects not...

journal_title：Respiratory medicine

authors： Boulay ME,Boulet LP

更新日期：2013-04-01 00:00:00

abstract：:We studied the validity of a recently introduced, handheld, electronic loading device in providing automatically processed information on external inspiratory work, power and breathing pattern during loaded breathing tasks in patients with COPD. Thirty-five patients with moderate to severe COPD performed an endurance ...

journal_title：Respiratory medicine

authors： Langer D,Jacome C,Charususin N,Scheers H,McConnell A,Decramer M,Gosselink R

更新日期：2013-04-01 00:00:00

abstract：:Behçet's disease (BD) is a multisystemic disease that may involve all systems, the most common symptoms being oral and genital ulcerations and ocular involvement. Pulmonary involvement is not usually investigated in BD unless there is a specific complaint. In this study, pulmonary parameters and findings were investig...

journal_title：Respiratory medicine

authors： Bilgin G,Sungur G,Kucukterzi V

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Up to 40% of patients seen in a cough clinic have unexplained chronic cough. The long term outcome of these patients is uncertain. OBJECTIVE:To determine the long-term outcome in patients diagnosed with unexplained chronic cough. METHODS:We have performed a longitudinal study of symptoms, airway inflamma...

journal_title：Respiratory medicine

authors： Yousaf N,Montinero W,Birring SS,Pavord ID

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:There are limited data on the role of adipokines in atopic asthma. AIM:To determine serum level of apelin-12 (APE-12) in asthmatic children in relation to BMI and gender. METHODS:Serum APE-12 levels were measured using ELISA in 89 asthmatic children (61 boys and 28 girls, aged 7.0-17.0 years) and in 33 hea...

journal_title：Respiratory medicine

authors： Machura E,Ziora K,Ziora D,Swiętochowska E,Krakowczyk H,Halkiewicz F,Kasperska-Zajac A

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Omalizumab is a recombinant humanized monoclonal anti-IgE antibody approved in adults and adolescents with moderate-to-severe persistent allergic asthma inadequately controlled with inhaled corticosteroids (ICS). EXCELS is an ongoing prospective observational cohort study of approximately 5000 omalizumab-tre...

journal_title：Respiratory medicine

authors： Chen H,Eisner MD,Haselkorn T,Trzaskoma B

更新日期：2013-01-01 00:00:00

abstract：:Increased levels of exhaled nitric oxide (FeNO) and airway hyperresponsiveness (AHR) to inhaled mannitol are related to allergic inflammation characterized by eosinophil infiltration and a clinical response to treatment with anti-inflammatory agents in subjects with asthma. This study determines the diagnostic accurac...

journal_title：Respiratory medicine

authors： Sverrild A,Malinovschi A,Porsbjerg C,Backer V,Alving K

更新日期：2013-01-01 00:00:00

abstract：:Few recent comparative data exist on smoking habits in the Middle East and North Africa (MENA) region. The objective of this analysis was to evaluate smoking patterns in a large general population sample of individuals aged ≥ 40 years in ten countries in the region (Algeria, Egypt, Jordan, Lebanon, Morocco, Saudi Arab...

journal_title：Respiratory medicine

authors： Khattab A,Javaid A,Iraqi G,Alzaabi A,Ben Kheder A,Koniski ML,Shahrour N,Taright S,Idrees M,Polatli M,Rashid N,El Hasnaoui A,BREATHE Study Group.

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Antibodies against mimivirus, a recently discovered giant virus, have been found in patients presenting with pneumonia suggesting a potential role for this virus as a respiratory pathogen. Several bacterial and viral pathogens have been associated with the occurrence of acute exacerbations in COPD. However...

journal_title：Respiratory medicine

authors： Vanspauwen MJ,Franssen FM,Raoult D,Wouters EF,Bruggeman CA,Linssen CF

更新日期：2012-12-01 00:00:00

abstract：RATIONALE:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia. The pathogenicity of IPF has been widely investigated but still remains to be clarified. Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of...

journal_title：Respiratory medicine

authors： Morimoto K,Janssen WJ,Terada M

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Little is known about trends in the utilization or complication rates of transbronchial lung biopsy, particularly in community hospitals. METHODS:We used the Healthcare Cost and Utilization Project Florida State Inpatient and State Ambulatory Surgical Databases to assess trends in transbronchial lung biopsy...

journal_title：Respiratory medicine

authors： Tukey MH,Wiener RS

更新日期：2012-11-01 00:00:00

abstract：:We compare the adequacy of several titration procedures of oxygen flow in maintaining SpO(2) > 90% during the activities of daily life in patients with very severe COPD. Thirty-one very severe COPD patients undergoing oxygen-therapy were recruited. Three titration methods were randomly performed: (1) 6-min walking tes...

journal_title：Respiratory medicine

authors： Galera R,Casitas R,Martínez E,Lores V,Rojo B,Carpio C,Llontop C,García-Río F

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:No consensus exists on the exact treatment of pneumothorax (PTX). Some guidelines are proposing manual aspiration (MA) to be preferred over tube thoracostomy (TT) in uncomplicated primary spontaneous pneumothorax (PSP). However, only a few studies reported a direct comparison of both methods. Our aim was to ...

journal_title：Respiratory medicine

authors： Parlak M,Uil SM,van den Berg JW

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Mycobacterium kansasii infection is one of the most common causes of nontuberculous mycobacterial lung disease in the world. However, it is not possible to differentiate completely between M. kansasii and other nontuberculous mycobacteria (NTM) because of a lack of direct comparative studies. This retrospect...

journal_title：Respiratory medicine

authors： Matveychuk A,Fuks L,Priess R,Hahim I,Shitrit D

更新日期：2012-10-01 00:00:00

abstract：:This manuscript offers an approach to the treatment of pulmonary sarcoidosis based on current available information. The treatment of pulmonary sarcoidosis is not mandatory as the disease may be self-limiting and therapy is often associated with significant drug side effects. The decision to treat rests predominantly ...

journal_title：Respiratory medicine

authors： Judson MA

更新日期：2012-10-01 00:00:00